5CAPSULE
Balancing Absorption with Dosage: Critical to Nootropic Nutrient Intake
3 min read

Essentials
- The 'macronutrient challenge' in nootropics involves creating capsules that can contain sufficient quantities of large-volume nutrients like Calcium and Magnesium without becoming overly large.
- While large capsules can be difficult to swallow and may cause gastrointestinal discomfort, there is a movement towards designing smaller capsules that still deliver the necessary nutrient benefits.*
The size of some nootropics can be off-putting for many. Ever tried gulping down one of those giant 'horse pills' and thought, 'There has to be a better way!'?
If the mere sight of large capsules or tablets makes you cringe, you're not alone. Many dread the idea of swallowing oversized pills, fearing discomfort or even a choking hazard.
But what if there was an alternative designed with user comfort in mind?
Here's a question for you. Which do you think matters most—absorption or dosage?
If your answer is 'both are equally important,' then you are correct. We believe the right balance between nutrient absorption and dosage in a nootropic is paramount for its efficacy.*
When a nutrient (be it a vitamin, mineral, amino acid, or any other nutrient) is present in a nootropic, its 'capacity' to be absorbed by your body is as significant as its dosage in the formula. This becomes even more pertinent when the nutrient is part of an encapsulated microbead.*
The dosage refers to the ratio of the nutrient to the substance it's bound to within the ingredient. This ratio determines the amount of nutrients that can fit into the capsule.
What is the 'macronutrient challenge,' or how can you get more from less?
Unless you don't mind taking a bunch of capsules at once or a so-called 'horse pill,' finding a nootropic with a delicate balance between absorption and dosage can be of huge importance.
This balance may become even more necessary for 'macronutrients,' which can take a lot of space within the capsule. Macronutrients, such as Calcium and Magnesium, are typically required in larger amounts by the body.*
→ Here's an example: Dicalcium Malate contains 29% elemental Calcium, whereas Calcium Citrate has only 19%. Achieving the same dosage requires more capsule space for the latter.*
→ Similarly, Dimagnesium Malate has a higher potency than Magnesium Bisglycinate, with 20% Magnesium compared to just 8%.*1
However, Magnesium Bisglycinate is slightly better absorbed than Dimagnesium Malate. This can make it a more suitable option in powdered nootropics.*
On the other hand, the higher Magnesium content in Dimagnesium Malate can make it an excellent choice for encapsulation.
Taking large capsules is a challenge for you? We have a solution.
It's no secret that large capsules (or tablets) filled with concentrated ingredients can be challenging for some folks to take. Even when taken with large amounts of water or juice.
Imagine taking a big pill, especially if you already struggle with swallowing, like those with dysphagia.2 It's not just uncomfortable; it can feel like you're choking.*
And it's not just about the size. These capsules can be tough on the stomach, causing unwanted adverse effects like discomfort or nausea. Plus, when you take in a lot of nutrients all at once, your body might not even absorb it all.*
And let's not forget the mental aspect; some people just don't like taking big pills because of past bad experiences or anxiousness.*
These are just some reasons HCF® advocates for a more balanced approach. And that's why we prioritize finding a balance between absorption and dosage.*
Smaller capsules, same benefits.*
We prioritize both size and bioavailability when designing our capsules. This way, your body can absorb and use the nutrients inside efficiently.*
It can also result in fewer unwanted adverse effects and a higher likelihood of you sticking to your daily nootropic routine.*
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. The contents of this website do not constitute advice and are provided for informational purposes only. See our full medical disclaimer
Sources
Meet Our Experts

Kerri Rachelle PhD c., RDN, LDN, CSSD, A-CFMP
Author, Linkedin
Author, Linkedin
Kerri Rachelle, a Registered Dietitian (RDN, LDN, CSSD, A-CFMP), PhD candidate in Integrative Medicine, and published author, specializes in nutrient absorption, cellular health, gut health, detoxification, and mental health. She is an international presenter for the Integrative and Functional Nutrition Specialist Certificate Program and the founder of Revolution Health, where she leads a team dedicated to sharing her expertise in natural practices that address the root causes of health issues, empowering health professionals worldwide.