6RELEASE
From Enzymes to Villi: The Vitamin Absorption Pathway Explained
3 min read

Essentials
- The small intestine is the primary site for nutrient absorption, facilitated by the intricate workings of villi and microvilli which increase the surface area for maximum nutrient uptake.*
- Ideally, nootropics need to mimic natural nutrient absorption processes to be more effective. This includes designing them to release active nutrients at the right time and place in the gut for optimal bioavailability and efficacy.*
Did you know that most nutrient absorption happens in the small intestine?*1,2 It's like a long, twisty tube where your food gets broken down even more, and all the good stuff gets absorbed into your bloodstream.
However, the process is super complex! It involves a bunch of different enzymes (plus saliva, acid, bile, and more).
Even the inside of the small intestine can play an important role here—it is covered with tiny, finger-like projections called villi and microvilli, which help absorb nutrients.3
These villi and microvilli soak up nutrients from food (and nootropics) into the blood vessels, carrying them throughout your body.
It's a multi-step process where each part plays an important role.
The primary function of your digestive system is to take the food you eat and break it down into smaller, more usable parts.
Enzymes.
After you eat, your food gets broken down by enzymes. This process starts in your mouth and continues in your stomach. Enzymes from your pancreas and bile from your liver mix with the food to break it down into its basic nutrients.
Small intestine.
Your small intestine absorbs the digested parts of your food, now transformed into simple sugars, amino acids, and fatty acids. Not to mention all the essential micronutrients from your diet.1
Villi and microvilli.
As mentioned, the inner walls of the small intestine are lined with tiny, finger-like projections (villi) and even smaller ones (microvilli). These structures create a huge surface area, making it easier to absorb nutrients.4 Think of them like little sponges soaking up all the good stuff.
Alright, let's break this down.
Most of the vitamins and minerals you get from food require a unique mechanism to cross the intestinal cell lining.
For example, vitamins fall into two categories: water-soluble (like the various B and C vitamins) and fat-soluble (like A, D, E, and K).
Water-soluble vitamins dissolve in water and are absorbed directly into the bloodstream. Drinking plenty of fluids can improve your body's ability to absorb and transport these nutrients.
On the other hand, fat-soluble vitamins—you may have guessed—require fat to aid in their absorption. That's why eating healthy fats with fat-soluble vitamin-rich foods may help your body properly absorb them.
What does this have to do with my favorite nootropic and brain health?
Absorption isn't just for food; it can apply to nootropics, too. For nootropics to be effective, they typically need to mimic these natural mechanisms.*
So, understanding how absorption works matters not only for cognitive health, but also for the health of your entire brain system (head, heart, and gut).
Just like how food is broken down, and nutrients are absorbed in the small intestine, nootropics can be designed to release their active nutrients at the right time and place in your gut.*
And since the brain and gut are in constant communication (the brain-gut axis), your gut health may directly impact your brain's performance and vice versa.*
Learning about your diet gaps may be the first step toward better nutrient absorption.
Everyone is unique. So, understanding digestion and your specific vitamin and mineral needs can be an important first step towards better cognitive health. It all boils down to how your body functions, your lifestyle, diet, goals, and the health of your various microbiomes.
At HCF®, we recognize these distinct absorption needs and have developed an innovative approach to nutrient delivery in our advanced nootropics.*
For instance, our time-release, multi-layered microbeads are designed to align with your body's natural digestive rhythms. This thoughtful design not only mimics how food is processed and absorbed but also enhances the bioavailability of each nutrient.*
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. The contents of this website do not constitute advice and are provided for informational purposes only. See our full medical disclaimer
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Meet Our Experts

Conor Sheehy PharmD, BCPS, CACP
Author, Linkedin
Author, Linkedin
Dr. Sheehy earned a BS in Molecular Biology from the University of Idaho and a Doctor of Pharmacy (PharmD) from the University of Washington. He is a Board-Certified Pharmacotherapy Specialist (BCPS) and a Certified Anticoagulation Care Provider (CACP). As a member of the American Medical Writers Association, the College of Psychiatric and Neurological Pharmacists (CPNP), and the National Alliance on Mental Illness (NAMI), his focus has been on innovative dosage deliverability strategies that primarily benefit individuals facing mental health challenges.