5CAPSULE
Better Digesting, Easier Swallowing: Why '0' vs '00' Capsules Are Changing Nootropics*
3 min read
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Essentials
- Smaller, size 0 / 0EL capsules typically dissolve faster in the stomach, allowing for quicker release of active nutrients into the digestive system.*
- Size 0 / 0EL capsules can cater to various groups, including individuals with swallowing difficulties, young adults, women, and people of smaller stature from different ethnic backgrounds.*
Did you know that size 00 capsules were a popular choice in many nootropics simply because they could pack in more active (and inactive) ingredients?
For years, nootropics brands have taken the "all but the kitchen sink" approach.
The idea was simple (but flawed): the more different nutrients you add, the higher the chance of hitting a few that may actually provide some cognitive support. However, this hit-or-miss approach often resulted in less effective overall formulations.*
That's not the case anymore. Health-conscious consumers now get that more isn't always better.
Packing in a bunch of nutrients often meant each one was in smaller amounts—sometimes even below the effective dose. Translation? It could potentially lead to a less noticeable impact because the dosage of each nutrient was likely not enough to provide significant benefits.*
At HCF®, we use compact size 0 / 0EL capsules.
Not only do they offer a better option for our microbead neuro-nutrient delivery, but they are also easier to dose and may dissolve faster in the body (compared to size 00 capsules).*
Plus, size 0 / 0EL capsules may be particularly beneficial for those with swallowing difficulties, young adults, women, and people of smaller stature of various ethnic backgrounds who may prefer a smaller, easier-to-swallow option.*1
Wait a minute. So, you are telling me that a capsule's size can affect the time it takes to dissolve? Indeed. When it comes to how long it takes for a capsule to dissolve, there's more to it than just saying, "It depends."
Did you know?
Size 0 / 0EL capsules can be made from a variety of materials, including gelatin and vegetarian-friendly options like Gellan Gum or HPMC (Hydroxypropyl Methylcellulose), catering to different dietary preferences and restrictions.
How long capsules take to dissolve relies on the size, type and amount of material in each capsule. In other words: taking one or two capsules at a time will be processed differently by your gut compared to taking, let's say, six or seven.
Size 0 / 0EL (and smaller) capsules may also enhance bioavailability.*
What does that mean? Your body may more effectively absorb and utilize the nutrients inside. This can make a crucial difference in getting the maximum benefit from the nootropics you take.*
Here's how it works:
- Faster Dissolution: Smaller capsules typically dissolve faster in the stomach. Active nutrients are released more quickly into your digestive system, making them available for absorption sooner.*2
- Uniform Distribution: A smaller, more concentrated dose may distribute the active nutrients more evenly in the digestive tract for better, consistent absorption rates.*
- Less Filler, More Active Nutrients: Size 0 / 0EL capsules often contain fewer fillers and binders, which can sometimes interfere with the absorption of the active nutrients. With fewer inactive components, there's often more room for the actual nutrients your brain system needs—and they may also be absorbed more efficiently.*3
- Optimized Surface Area: The surface area-to-volume ratio is higher in smaller capsules, which may improve the interaction with digestive enzymes. This may help break down the capsule and its contents more efficiently.*2
Did you know?
Size 0 / 0EL capsules are often preferred in clinical trials and research studies because their consistent size and fill volume help provide accurate dosing and reliable results.1
There's simply no need for larger capsules.
Period. Our size 0 / 0EL capsules are sufficient for our targeted nootropics. They provide enough capacity to include the necessary dosages of our recognizable and premium neuro-nutrients (without unnecessary fillers, binders, and additives).
With our 7 Advances® principles, you can rest assured that you're getting only what you need for optimal cognitive support without any unnecessary extras.
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. The contents of this website do not constitute advice and are provided for informational purposes only. See our full medical disclaimer
Sources
Meet Our Experts

Conor Sheehy PharmD, BCPS, CACP
Author, Linkedin
Author, Linkedin
Dr. Sheehy earned a BS in Molecular Biology from the University of Idaho and a Doctor of Pharmacy (PharmD) from the University of Washington. He is a Board-Certified Pharmacotherapy Specialist (BCPS) and a Certified Anticoagulation Care Provider (CACP). As a member of the American Medical Writers Association, the College of Psychiatric and Neurological Pharmacists (CPNP), and the National Alliance on Mental Illness (NAMI), his focus has been on innovative dosage deliverability strategies that primarily benefit individuals facing mental health challenges.