Rethinking Preservatives: BHT & BHA's Influence on the Endocrine System

Did you know that BHT & BHA—two synthetic antioxidants—are often found in nootropics, cosmetics, and even some foods?

While they may serve a purpose as preservatives, there's a growing concern about their safety. The problem? Their possible link to a number of health challenges, including endocrine system disruptions.*

First things first: what are BHT & BHA?

Chances are you stumbled upon these two excipients on a label and breezed past without a second thought. Well, you might want to take a closer look next time!

BHT & BHA are synthetic antioxidants used in many nootropics to preserve the active nutrients’ integrity and extend product shelf life.

When it comes to their safety, studies show mixed results.

On the positive side, research highlights their antioxidant properties. For example, a study published in the International Journal of Molecular Sciences demonstrated that BHT and BHA effectively inhibit lipid oxidation, which helps maintain the quality and freshness of food products. This antioxidant activity can also protect cells from oxidative damage, potentially reducing the risk of certain diseases.*

Conversely, other studies have raised significant health concerns about BHT and BHA. For instance, BHA has been classified as "reasonably anticipated to be a human carcinogen" by the National Toxicology Program¹ and is listed under California’s Proposition 65 as a known carcinogen.*²

Endocrine what?

Ever heard of the term 'endocrine disruptor' and wondered what on earth it means? The World Health Organization (WHO) has a pretty technical definition, but don't worry, we're here to break it down for you.

Now, according to WHO, an endocrine disruptor is “an exogenous substance or mixture that alters function(s) of the endocrine system and consequently causes adverse health effects in an intact organism, or its progeny, or (sub) populations.”

That's a head-scratching explanation, right?

Well, let's put this in simpler terms: Endocrine disruptors can pose a health hazard because they can interfere with our natural hormonal functions.

They can disrupt hormone production by interfering with the mechanisms responsible for their synthesis, transport, biodegradation, or elimination. They can also cause issues by mimicking the actions of our natural hormones—which can lead to problems when those specific hormonal functions are not needed. Additionally, they can block hormone function by occupying their place on receptors.^4,5

According to the European Commission on Endocrine Disruption, BHA has been classified as a Category 1 priority substance due to its demonstrated interference with hormone function.*^6,7

Some studies suggest that high doses of BHT can mimic estrogen and prevent the expression of sex hormones, including testosterone, which can impact reproductive health.*³

So, what can you do to avoid these potentially harmful additives?

BHA & BHT can still be used in nootropics (and foods) under specific regulations in the United States. However, international laws, particularly in the European Union, have more stringent guidelines. For example, the EU restricts the BHT's concentration in many products.

Integral to our 7 Advances®, our commitment to clean label principles goes beyond mere avoidance of unnecessary fillers, binders, and additives. At HCF®, we are committed to a holistic approach in developing advanced nootropics that contain only premium neuro-nutrient forms. Our products are designed to feed and nourish all three brains—head, heart, and gut—for a synergistic effect that promotes overall health and cognitive function.*