Methylated vs. Non-Methylated: How Your Genes Influence Vitamin Absorption

Many are curious about the concept of methylated vitamins. Methylated vs. non-methylated vitamins is a novel concept that has gained traction with the introduction of 'active' B vitamin forms in nootropics.

But why are methylated vitamins so sought after? Read on to learn more about the difference between methylated and non-methylated vitamins, what the MTHFR mutation is (and why it may affect you without even knowing), if you should consider taking methylated vitamins, and more.

First things first: what is methylation?

Methylation. Sounds complex, right? Well, it's not that difficult to understand. At its core, methylation involves adding a methyl group (a carbon atom bonded to three hydrogen atoms) to another molecule. This tiny change can have a significant impact, especially when it comes to DNA function and expression.*¹

But, not all nutrients can undergo this process. Here are some of the most commonly methylated nutrients:

• L-5-MTHF or L-5-Methyltetrahydrofolate (an 'active' form of Folate, also known as just L-Methyl Folate)
• S-Adenosyl-L-Methionine (SAMe)
• Trimethylglycine (Betaine or TMG)
• Phosphatidylcholine
• Methylcobalamin (an 'active' form of Vitamin B12)
• Choline
• Inositol

Methylated vitamins have undergone this process, making them more bioavailable (better absorbed). In fact, methylation plays a role in a number of biological processes, including melatonin production (for restful sleep), properly regulating important hormones, and supporting neurotransmitters that may maintain focus and a positive mood.*^2,3

All about the MTHFR gene (and why it matters).

Better and faster absorption? Sounds ideal. But there's more beneath the surface of this rising nutrient trend, though. That's where something called the MTHFR gene mutation comes in.*

Everyone is born with a pair of MTHFR genes (gifted from both parents). Either or both can be mutated. When there is no MTHFR gene mutation, this gene aids in breaking down homocysteine (a type of amino acid) by using Folic Acid and other B vitamins.*⁴

But if you have an MTHFR mutation (a condition affecting up to 60% of the general populace),⁵ this may not happen the way it's supposed to. You see, without proper MTHFR function, your body struggles to transform Folic Acid into its usable counterpart, Folate.*⁶

The result? Some studies suggest a correlation between high homocysteine levels and certain health challenges.*^7,8

Methylated vs. non-methylated vitamins: why it's not just apples to apples.

Choosing vitamins isn't a one-size-fits-all game. It's personal. So, what's the deal with methylated and non-methylated vitamins?

Well, methylated vitamins are an option for those requiring extra methylation support due to a slow Folate pathway, MTHFR gene variations, elevated homocysteine levels, and other methylation challenges.*

Consider methylated vitamins as shopping for a new bicycle. You're faced with two choices: buy the parts and assemble it on your own, or get a fully assembled bike, ready for action. You'd naturally lean towards the ready-to-go bike if you're itching for a ride immediately. 

For those with the MTHFR mutation, the assembled bike may be a necessity since they can't piece one together themselves. This ready-to-go choice also gets everyone else pedaling quicker.

Methylated vitamins work in a similar fashion. They're already in their active form, allowing for better absorption compared to unmethylated nutrients. In short, your body can use those nutrients a lot faster.*

Take Vitamin B12, for example. It comes in two main forms: Methylcobalamin (methylated) and Cyanocobalamin (non-methylated). For someone with an MTHFR mutation, Methylcobalamin might be the better choice.*

Should you look for methylated nutrients?

What's important to understand is this: methylated or not, these nutrients are not energy drinks. They shouldn't be taken with the same energy-boost-then-crash expectations. As with all nutrients, there are some caveats to the benefits of methylated vitamins.

Given that those with an MTHFR mutation may not get the most out of conventional vitamins, they can significantly benefit from a methylated option.*

That said, nootropics with methylated nutrients, such as HCF®, are formulated for absorption. Vegans and vegetarians, in particular, may want to add methylated vitamins to their routine, given their diets might lack certain nutrients, like Vitamin B12.*