1NUTRIENTS
Why DL-Phenylalanine?
3 min read

Essentials
- D-Phenylalanine helps block enzymes that break down natural physical discomfort relievers like endorphins and enkephalins, potentially reducing discomfort.*
- L-Phenylalanine is a precursor to neurotransmitters such as dopamine, norepinephrine, and epinephrine, supporting mood, alertness, and cognitive function.*
DL-Phenylalanine (DLPA) stands out as a unique and potentially more effective combination of two already potent forms of the amino acid Phenylalanine: D-Phenylalanine (D) and L-Phenylalanine (L).
While each form carries distinct characteristics and benefits, DL combines the ‘D’ and ‘L’ forms, resulting in a sought-after nutrient that offers the advantages of both types.
Too head spinning and complicated? Alright, let's break it down a bit.
Think of D-Phenylalanine as one half of a dynamic duo. Its primary benefit? It may play a role in the body's response to physical discomfort.*
Simply put, it helps block the enzymes that break down our natural discomfort killers—endorphins and enkephalins.1 With D-Phenylalanine's help, our body can continue to produce these natural relievers, often helping us experience less discomfort.*
Switch gears. L-Phenylalanine, the counterpart, leans more toward cognitive functions.
It's a precursor to neurotransmitters like dopamine, norepinephrine, and epinephrine—three essential hormones responsible for mood, alertness, and overall cognitive function.2 Thus, L-Phenylalanine has been studied for its potential influence on neurotransmitter production.*
So, what exactly makes DL-Phenylalanine the preferred choice?
You now probably wonder, “Why do I need DL-Phenylalanine if D and L forms already can do so much for my overall brain health?” Simple. Because DL-Phenylalanine combines aspects of both 'D' and 'L' forms, which may offer a broader range of potential benefits in terms of mood, cognitive support, attention, focus, AND ... often with fewer downsides.*3,4,5,6
Here's a quick breakdown:
And here's something else you may find quite interesting: with DL-Phenylalanine, your body can also produce more Tyrosine, which can boost dopamine production even further. Why is this important? Because having more dopamine means you'll likely feel better and more positive overall.7 It’s another win-win for DLPA.*
How to start feeding your brain.
A balanced diet is essential for overall health and well-being. And getting Phenylalanine from foods is preferred.
Incorporating these into your diet can naturally boost Phenylalanine levels.
However, only the L-form of Phenylalanine is present in the foods we consume, as it is the natural form found in proteins. That's why HCF® prefers DL-Phenylalanine for the A20® advanced nootropic formulation.
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. The contents of this website do not constitute advice and are provided for informational purposes only. See our full medical disclaimer
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Meet Our Experts

Kerri Rachelle PhD c., RDN, LDN, CSSD, A-CFMP
Author, Linkedin
Author, Linkedin
Kerri Rachelle, a Registered Dietitian (RDN, LDN, CSSD, A-CFMP), PhD candidate in Integrative Medicine, and published author, specializes in nutrient absorption, cellular health, gut health, detoxification, and mental health. She is an international presenter for the Integrative and Functional Nutrition Specialist Certificate Program and the founder of Revolution Health, where she leads a team dedicated to sharing her expertise in natural practices that address the root causes of health issues, empowering health professionals worldwide.